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Faculty of Science and Arts - Khulais
Document Details
Document Type
:
Article In Journal
Document Title
:
Stereoselective Synthesis and Antiviral Activity of (1E,2Z,3E)-1-(Piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol- 2-oyl)hydrazono]-4-(aryl1)but-3-enes.
تشييد مركبات الداى هيدرازون و اثبات التركيب الفراغى لها كمضادات للفيروسات
Subject
:
Organic Chemistry
Document Language
:
English
Abstract
:
The reaction of benzoyl hydrazine1aor benzothiazole-2-carbohydrazide1bwith 2-oxo-N-arylpropanehydrazonoyl chlorides 2a-dyielded (1Z,2E)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-N-(aryl)propanehydrazonoyl chlorides3a-e. The reaction of3a-c with sodium benzenesulphinate furnished sulfones5a-c while the reaction of5d,e with hydroxyl amine afforded hydroxomoyl derivs.6a, b. The one-pot sterioselective reaction ofN-(aryl)propanehydrazonoyl chlorides3 with certain arom. aldehydes in the presence of piperidine resulted in the formation of (1E,2Z,3E)-1-(piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-4-(aryl1)-but-3-enes7a-g. X-ray anal. of piperidinyl amidrazone 7gshowed a conversion of its geometrical structure with respect to that of compd.3 and confirmed the stereoselectivity of the latter reaction. The piperidinyl amidrazones7a-g possessed a significant antiviral activity against herpes simplex viruses (HSV-1). Compd. 7d reduced the no. of viral plaques of herpes simplex type-1 (HSV-1) by 67%, with respect to the effect of ref. drug Aphidicolin.
ISSN
:
1319-0989
Journal Name
:
Arts and Humanities Journal
Volume
:
343
Issue Number
:
3
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Saturday, December 25, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
بكر فتحى عبد الوهاب
Abdel-Wahab, Bakr Fathi
Researcher
Doctorate
Files
File Name
Type
Description
28233.pdf
pdf
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