Document Details

Document Type : Article In Journal 
Document Title :
Histopathologic changes in liver and kidney in albino mice feed with aflatoxin M1
Histopathologic changes in liver and kidney in albino mice feed with aflatoxin M1
 
Document Language : Arabic 
Abstract : The daily oral administration of contaminated milk with AFM1(0.11ng/0.1ml milk /day) for 6 months caused sever damage in both liver and kidney tissue of albino mice. Histopathological examination of liver tissue of mice feed with M1 revealed that there is a damage in the liver cells presented by apoptosis, appearance of intramuscular inclusion and even necrosis. The histopathological examination of the kidney tissues showed remarkable damage in cells lining the renal tubules with protein precipitation inside these casts and become vacuolated with inflammation in some blood vessels. Addition of vitamin C (0.50 mg /0.1 ml milk /day) caused partially improvement in both liver and kidney tissues. The histopathological changes in liver and kidney tissues in mice feed with M1 indicated the sever toxicity of aflatoxinM1 and the improvement of these changes after the administration of vitamin C, which acts as an antioxidant agent. 
Journal Name : Saudi Journal of Biological Sciences 
Volume : 15 
Issue Number : 1 
Publishing Year : 2008 AH  
Added Date : Tuesday, June 17, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أ.د. صالح محمد صالح القرنيSaleh M. Al-GarniResearcher Saleh895_4@hotmail.com
ناصر الحازميNasser A. Al-HazmiResearcher  
.Al-Saeed F. Al-SaeedResearcher  

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