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Document Type |
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Article In Journal |
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Document Title |
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Intravenous acetaminophen vs oral ibuprofen in combination with morphine PCIA after Cesarean delivery. Intravenous acetaminophen vs oral ibuprofen in combination with morphine PCIA after Cesarean delivery. |
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Document Language |
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English |
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Abstract |
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Alhashemi JA, Alotaibi QA, Mashaat MS, Kaid TM, Mujallid RH, Kaki AM.
Department of Anesthesia & Critical Care, King Abdulaziz University, King Abdulaziz University Hospital, Jeddah 21418, Saudi Arabia. jalhashemi@kau.edu.sa
PURPOSE: To compare the effects of iv acetaminophen with those of oral ibuprofen with respect to postoperative pain control and morphine requirements in patients receiving morphine patient-controlled iv analgesia (PCIA) after Cesarean delivery. METHODS: Forty-five term patients scheduled for Cesarean delivery were randomized to receive acetaminophen 1 g iv every six hours plus oral placebo (group A) or ibuprofen 400 mg po every six hours plus iv placebo (group I); the first dose of study drug was given 30 min preoperatively. Postoperatively, all patients received PCIA for 48 hr using morphine bolus dose 2 mg iv, lockout interval ten minutes, and no basal infusion. Visual analogue scale (VAS; 0 to 10) at rest and morphine requirements were recorded every hour for four hours then every four hours for a total of 48 hr postoperatively. Patient satisfaction was recorded on a ten-point scale (from 1 to 10) 48 hr postoperatively. RESULTS: Visual analogue scale scores decreased similarly in both groups over time, however, there were no differences between groups at any time during the study period (estimated marginal means: 1.4 +/- SEM 0.2 vs 1.9 +/- SEM 0.2 for groups A and I, respectively, P = 0.124). Cumulative doses of postoperative morphine were 98 +/- 37 vs 93 +/- 33 mg for groups A and I, respectively (P = 0.628). Patient satisfaction with analgesia was high in both groups (9 +/- 1 vs 9 +/- 1, P = 0.93). CONCLUSION: Intravenous acetaminophen is a reasonable alternative to oral ibuprofen as an adjunct to morphine patient-controlled analgesia after Cesarean delivery.
PMID: 17142654 [PubMed - indexed for MEDLINE] |
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ISSN |
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17142654 |
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Journal Name |
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Can J Anaesth |
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Volume |
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53 |
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Issue Number |
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12 |
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Publishing Year |
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2006 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, March 21, 2010 |
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Researchers
| جمال الهاشمي | Alhashemi, Jamal | Researcher | Doctorate | |
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