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Document Type |
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Article In Journal |
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Document Title |
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Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery. Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery. |
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Document Language |
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English |
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Abstract |
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Alhashemi JA.
Department of Anesthesia and Critical Care, King Abdulaziz University, King Abdulaziz University Hospital PO Box 31648, Jeddah, Saudi Arabia. jalhashemi@kau.edu.sa
BACKGROUND: Cataract surgery is commonly performed under local anaesthesia with midazolam sedation. Dexmedetomidine, a sedative-analgesic, is devoid of respiratory depressant effects, and its use in cataract surgery has not been reported. This double-blind study compared the use of dexmedetomidine and midazolam in patients undergoing cataract surgery. METHODS: Forty-four patients undergoing cataract surgery under peribulbar anaesthesia randomly received either i.v. dexmedetomidine 1 microg kg(-1) over 10 min; followed by 0.1-0.7 microg kg(-1) h(-1) i.v. infusion (Group D), or midazolam 20 microg kg(-1) i.v.; followed by 0.5 mg i.v. boluses as required (Group M). Sedation was titrated to a Ramsay sedation score of 3. Mean arterial pressure (MAP), heart rate (HR), readiness for recovery room discharge (time to Aldrete score of 10), and patients' and surgeons' satisfaction (on a scale of 1-7) were determined. RESULTS: MAP and HR were lower in Group D compared with Group M [86 (se 3) vs 102 (3) mm Hg and 65 (2) vs 72 (2) beats min(-1), respectively] (P<0.05). Group D patients had slightly higher satisfaction with sedation [median (IQR): 6 (6-7) vs 6 (5-7), P<0.05], but delayed readiness for discharge [45 (36-54) vs 21 (10-32) min, P<0.01] compared with patients in Group M. Surgeons' satisfaction was comparable in both groups [5 (4-6) vs 5 (4-6)]. CONCLUSION: Compared with midazolam, dexmedetomidine does not appear to be suitable for sedation in patients undergoing cataract surgery. While there was a slightly better subjective patient satisfaction, it was accompanied by relative cardiovascular depression and delayed recovery room discharge.
PMID: 16595611 [PubMed - indexed for MEDLINE] |
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ISSN |
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16595611 |
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Journal Name |
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Br J Anaesth |
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Volume |
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96 |
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Issue Number |
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6 |
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Publishing Year |
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2006 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, March 21, 2010 |
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Researchers
| جمال الهاشمي | Alhashemi, Jamal | Researcher | Doctorate | |
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