Document Details

Document Type : Article In Journal 
Document Title :
Glial intranuclear inclusion bodies in a patient with Alzheimer's disease.
Glial intranuclear inclusion bodies in a patient with Alzheimer's disease.
 
Document Language : English 
Abstract : We report a case of dementia in an elderly woman with the pathological findings of Alzheimer's disease and numerous intranuclear inclusions in astrocytes and occasionally in neurons. These inclusions were seen in the cerebral cortex, limbic areas, basal ganglia, thalamus, brain stem and cerebellum. They expressed ubiquitin and were ultrastructurally composed of haphazardly arranged straight filaments. The presence of similar intranuclear inclusions in previous cases of adult-onset dementia without other neuropathological changes suggests an important link between these kind of inclusions and dementia. To our knowledge, this type of intranuclear inclusions has not been previously described in association with Alzheimer pathology. 
ISSN : 10867805 
Journal Name : Acta Neuropathol. 
Volume : 99 
Issue Number : 6 
Publishing Year : 2000 AH
2000 AD 
Article Type : Article 
Added Date : Sunday, April 11, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جودة المغربيAl-Maghrabi, Jaudah InvestigatorDoctorate 

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 26397.doc doc 

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