Document Details

Document Type : Article In Journal 
Document Title :
Rosai-Dorfman disease of the larynx. A case report with molecular genetic analysis
Rosai-Dorfman disease of the larynx. A case report with molecular genetic analysis
 
Document Language : English 
Abstract : Sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai- Dorfman disease (RDD), is rare histiocytic disorder originally described in 1969 as a benign Clinicopathologic entity characterized by massive bilateral cervical lymphadenopathy and fever. The indolent clinical course of RDD suggests a reactive disorder rather than a neoplastic process. We present a 21 year- old woman with RDD of the larynx with a recurrence of the disease after 13 months. To determine whether the lymphoplasmacytic components in these lesions clonal or polyclonal we performed a molecular testing using PCR and southern blot analyses to examine Immunoglobulin (JH) and T-cell receptor genes (TCR) genes rearrangement. The analysis showed polyclonal pattern (germline) for JH and TCR. Surface marker analysis by flow cytometry and immunohistochemistry revealed a mixed population of T and B cells with no evidence of light or heavy chain restriction. This indicates that the lymphoplasmacytic proliferation in RDD is reactive and consistent with the indolent behavior. 
ISSN : 0306-4522 
Journal Name : Mansoura Medical Journal 
Volume : 37 
Issue Number : 3-4 
Publishing Year : 2006 AH
2006 AD 
Article Type : Article 
Added Date : Sunday, April 11, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جودة المغربيAl-Maghrabi, Jaudah InvestigatorDoctorate 

Files

File NameTypeDescription
 26416.doc doc 

Back To Researches Page