Document Details

Document Type : Article In Journal 
Document Title :
IMMUNOPATHOLOGICAL STUDY FOR LAMININ·5 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
IMMUNOPATHOLOGICAL STUDY FOR LAMININ·5 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
 
Document Language : English 
Abstract : Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity. In recent years, strong evidence has accumulated suggesting that the disturbance in extracellular matrix may play a role in the pathogenesis of some human neoplasms. Therefore, an analysis of the extracellular matrix in the invasion front of oral squamous cell carcinoma (OSCC) may improve the understanding of tumor cell matrix interactions during malignant growth. The present work was undertaken to study the immullo-hiotochemical expressions of Ln- 5γ 2 in OSCC, in correlation to the histologic grades and clinical stages and finally to study Ln-5γ 2 as an angiogenic factor. Highly significant positive correlation was found between Ln-5γ 2 expression and the degree of differentiation of OSCC cases. Ln-5γ 2 as an angiogenic factor was found to be non specific for angiogenesis assessment. Also a positive statistical correlation was found between blood vessel count and degree of differentiation in OSCc. It was concluded that the extent of Ln-5γ2 expression outside the basement membrane (BM), as well as the loss of Ln-5γ 2 from the BM was of prognostic value. 
ISSN : 0 
Journal Name : Egyptian Dental Journal 
Volume : 51 
Issue Number : 1 
Publishing Year : 2005 AH
2005 AD 
Article Type : Article 
Added Date : Monday, May 19, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منال النويعمEl Nouaem, Manal ResearcherDoctorate 

Files


Download This Page

Back To Researches Page