Document Details

Document Type : Thesis 
Document Title :
HISTOLOGICAL STUDIES ON THE EFFECT OF BALESSAN SAP, COMMIPHORAOPOBALSAMUM (L.) FOR PROMOTION OF FULL THICKNESS WOUND HEALING IN RATS
دراسات نسیجیة عن تأثیر عصارة (البیلسان) (كومیفورا أوبوبالساموم)كمحفز لإلتئام جرح كامل السمك في الجرذان
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Large skin wounds are challenging clinical problem as its is liable to infection and complication. Natural herbal products were tried for promoting wound healing. In this study, Commiphora opobalsamum L. (Balessan) was used for remodoling of full thickness wound in rats. Male rats (n=40) were sorted to, GI: unwounded rats (n=4), GII: full-thickness wounded (1.5cm×1.5cm) which divided into: GII-a: non-treated wound, GII-b: treated wound groups: each is subdivided into 3 subgroups at 7th days (n=6), at 14th days (n=6) and at 21st day (n=6). Signs of wound healing were photographed. Wounded area is dissected and histological sections were stained by hematoxylin and eosin, Masson’s. immunohistochemistry for (PCNA), (CD68) and (VEGF) for histological differences. Balessan was found to be effectively promote full thickness wound healing based on the increase of contraction rate with enhanced re-epithlization and decreased inflammtory reaction in wounded area. Immunohistochemistry for (PCNA) and (VEGF) showed more postive reaction in treated wound groups, (CD68) for macrophages showed increased expresion in (7th and 14th) days in both groups. Hematological study showed decrease in white blood cells at eaarly stages then increase to normal at (21st) in treated group. Balessan analysis showed anti-bacterial and anti-inflammtory elements that explained its enhanching healing effect. Future clinical trial is needed for fuse as a topical therapy. 
Supervisor : Prof. Dr. Omar Rabah 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Co-Supervisor : Prof. Saad Shaker 
Added Date : Thursday, May 16, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شذى فوزي الأحمديAlahmadi, Shada FauziResearcherMaster 

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