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Document Type |
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Thesis |
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Document Title |
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Hypoglycemic and Hypolipidemic Effects of Solanum Nigrum Leaf Extract on Male Diabetic Rats تأثير مُستخلص أوراق عنب العرقد في خفض مستوى السكر والدهون في الدم على الجرذان المصابة بالسكري |
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Subject |
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Faculty of Human Sciences and Designs |
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Document Language |
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Arabic |
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Abstract |
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Diabetes (DM) is a group of complex and chronic metabolic disorders with diverse multiple etiologies. Long-term complications may affect the organs such as kidneys, eyes, nerves, heart and blood vessels. Solanum nigrum water leaves extract (SNWLE) are among the herbs used for controlling hyperglycemia in conventional medicine. This study was conducted to evaluate the potential effect of SNWLE in streptozotocin (STZ) - induced diabetic rats. Forty male adult Wister rats were distributed to five groups (8 rats each) and were studied as following scheme for 8 weeks, group (I) normal control (cont.( -)),group (II) diabetic control rats were given distilled water daily by gastric incubation (cont.(+) ),group (III) diabetic rats were treated orally with glimepiride (GI) (1 mg/kg/day), groups (IV) and (V) diabetic rats were treated orally with SNWLE (250 mg/kg /day) and SNWLE (250 mg/kg /day) combined with GI (1 mg/kg/day), respectively. Blood samples, pancreas and kidneys were collected at the last day of the experimental period (8 weeks) for biochemical parameters estimation as well as the histopathological examinations. The SNWLE and/or glimepiride administration to diabetic rats reduced significantly blood glucose (BG) level, lipid profile parameters, kidneys function parameters and MDA. On the other hand, the levels of insulin (INS),HDLc.,GSH, SOD, GPx, and CAT were significantly increased compared with cont. (+). Moreover, the extract showed significant amelioration in pancreatic and kidneys cells structure. These findings demonstrated that SNWLE might exert a treatment role against DM via its antioxidant mechanism.
Keywords: Diabetes- Histology- Rats- Antioxidant- Solanum nigrum - Streptozotocin |
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Supervisor |
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Dr. Reham Arafat |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Monday, May 25, 2020 |
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Researchers
| آمنة ماجد درويش | Darwish, Amnah Majid | Researcher | Master | |
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