Document Details
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Document Type |
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Thesis |
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Document Title |
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he Role of Vitamin D3 Supplementation on Hepatic Renin Angiotensin System Changes in Experimental Model of Metabolic Syndrome دور مكملات فيتامين د3 في تغيرات نظام الرينين أنجيوتنسين الكبدي في النموذج التجريبي لمتلازمة التمثيل الغذائي |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Metabolic syndrome (MetS) is a term used to describe a cluster of pathophysiological, biochemical, and metabolic criteria; including high blood pressure, high cholesterol, dyslipidaemia, central obesity, and insulin resistance. The renin angiotensin system (RAS) has a regulatory function in blood pressure, hydroelectrolyte balance, and cardiovascular function. RAS is composed of angiotensinogen, (Ang-I), (Ang-II), (ACE1), (ACE2), (AT1 R), (AT2R), and (Ang 1-7). Also, RAS components are produced and act locally in multiple tissues which is called local RAS. Vitamin D takes a huge part in the mechanisms of calcium homeostasis and bone metabolism. Also, Vitamin D had been proved to act as a protective factor against MetS. So, the study pursued to explore vitamin D supplementation roles on hepatic RAS in metabolic syndrome experimental model. 36 males Albino rats were separated into 4 groups: control group. Vitamin D group were given 500 IU/Kg/day of vitamin D3 daily by oral gavage. MetS group were induced to have MetS by giving 20% fructose solution in drinking water daily. MetS + vitamin D, which supplemented with vitamin D3 (MetS + Vit D), received 20 percent of fructose solution and vitamin D in a daily dose of 500 IU/Kg/day, orally via gavage. Body mass index (BMI) was measured weekly, and blood pressure was measured every two weeks for 3 months. Then, data collected from blood samples and RNA extracted from liver were analyzed using biochemical and statistical analysis tests. As a result, the major finding was proving that vitamin D can balance the expression of ACE1 and ACE2. Also, confirmed that it can improve MetS components by elevating the high-density lipoprotein and insulin levels while reducing blood pressure, levels of cholesterol, low-density lipoprotein, triglyceride, glucose, alanine aminotransferase, Aspartate Aminotransferase and insulin resistance. These outcomes may give a new insight into the hepatic RAS pathways associated with MetS. |
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Supervisor |
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Prof. Ahlam Abdulaziz Alahmadi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Prof. Zienab Abdelhafiz Alrefaie |
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Added Date |
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Saturday, September 30, 2023 |
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Researchers
| سارة محمود محتر | Mohater, Sara Mahmood | Researcher | Master | |
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